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- Mammalian Red Blood Cells
- Provided initial evidences that biological membranes consist of lipid bilayers (E. Gorter & F. Grendel, 1925).
- Since, they do not contain nuclei or internal membranes, thereby becoming a source from which pure plasma membrane can be isolated easily.
- RBCs’ plasma membrane have been particularly useful as a model for membrane structure studies.
- The
plasma membrane of animal cells quantitatively contain-
- Four
major Phospholipids (accounting in total more than half of the lipids in most
membranes):
- Phosphatidylcholine (Phospha-ti-dyl-choline)
- Phosphatidylethanolamine (Phospha-ti-dyl-ethanol-amine)
- Phosphatidylserine (Phospha-ti-dyl-serine)
- Sphingomyelin (Sphingo-myelin)
- One
minor Phospholipid:
- Phosphatidylinositol (Phospha-ti-dyl-inositol)
- Four
major Phospholipids (accounting in total more than half of the lipids in most
membranes):
- In
the outer leaflet of Plasma membrane following phospholipids are present:
- Phosphatidylcholine
- Sphingomyelin
- In
the inner leaflet of Plasma membrane following phospholipids are present:
- Phosphatidylserine
- Phosphatidylethanolamine
- Phosphatidylinositol
To be continued…